Another function of tone-change is noun specialization and/or semantic shift.

For an example of specialization, we can take a look at the word 城 [siaŋ22] city/town. A change in tone to 225 would mean specifically the town of Taicheng (台城), the county seat and largest town in Taishan. To residents of the town, it would be just the couple of blocks where the town originated.

By the way, 城 is widely used to name county seats in the Pearl River Delta area, i.e. 会城 is the county seat of 新会 (Xinhui), and 莞城  of 东莞 (Dongguan, now a pop. 5 million+ city sandwiched between Guangzhou and Shenzhen). 广州 (Guangzhou/Canton) is also known as 省城 [saŋ55 siaŋ22]-- the provincial city.

鼻 [bi32] is nose, but a change in tone to 鼻 [bi325] would turn it into nasal mucus -- a case of semantic shift. Thus a running nose is 流鼻 [liu22 bi325].

Here are some more examples:

Normal Tone Changed Tone Normal Tone Changed Tone
烟 [yan] 33 335 smoke tobacco
袋 [ɔi] 32 325 bag, sack a pocket
糖 [hɔŋ] 22 225 sugar candies
头 [həu] 22 225 head leader
妹 [mɔi] 55 21 young girl younger sister
月 [ŋut] 32 215 month the moon
公 [gǝŋ] 33 215 old person (of animal/insect) a male; (of chess) the King
墨 [mak] 32 215 ink a mole
山 [san] 33 21 mountain, hill a burial heap
尺 [tsiak] 33 21 measurement unit of one foot a ruler
二 [ŋi] 32 215 the number two (intimate) the second son; (playing cards) a card of rank two
拳 [kun] 22 225 fist a set or style of Martial Arts
脚 [giak] 33 21 feet, leg dregs
银 [ŋan] 22 225 silver money
皮 [pi] 22 225 skin fur, leather
针 [dzim] 33 215 sewing needle injection needle
日头 [ŋit hǝu] 33-21 21-215 the sun day time
鸡笼 [gai lǝŋ] 33-21 33-215 chicken cage a type of fried dumpling (shaped like a chicken cage)
火头 [fɔ həu] 55-22 55-225 source of fire; seeds of trouble a cook